This is a story-based role-playing game (RPG) based on the television hospital drama, Grey's Anatomy. Players take on the roles of various doctors and surgical interns who perform various medical procedures on ailing patients. Mini-games can include removal of foreign objects, setting bones and connective tissue, suturing lacerations and incisions, treating burns, and suctioning blood. A cutscene depicts a doctor punching another doctor in the face and a character bleeding after being thrown against a glass cabinet. The storyline contains frequent references to sexual encounters between different characters and dialogue that contains sexual innuendo (e.g., "Is there anyone in this hospital you're not trying to sleep with?" and "You wanna have sex after the surgery?"). One scene depicts a character opening a door on a doctor having sex with a patient. Although the sex act is not shown, brief moaning can be heard. Dialogue also contains mild expletives (e.g., "hell" and "a*s") and references to alcohol (e.g., "You me, at a restaurant, bottle of wine").
